Title: The relationship and significance of HIF-1α and Cox-2 in gastric cancer
Abstract: Objective:To study the expression of HIF-1α and Cox-2 in gastric cancer and their relationship with tumor angiogenesis,clinicopathologic feature and prognosis. Methods: Immunohistochemical technique was used to detect the expression of HIF-1α and Cox-2 in 54 cases of gastric cancer.The relationship between the expression of HIF-1α, Cox-2 and tumor angiogenesis,clinicopathologic feature of patients was analyzed. Results: The positive expression rate of HIF-1α in gastric cancer(74.07%) was significantly higher than that in normal gastric tissue(0%), P0.01; The expression of HIF-1α in gastric cancer was significantly associated with TNM stage, invasive depth and lymph-node metastasis, P 0.05 or P0.01. The expression of Cox-2 in gastric cancers was (62.9%) significantly higher than that in normal gastric tissue(6.67%),P0.01; The expression of Cox-2 in gastric cancer was significantly associated with TNM stage, histological grade and lymph-node metastasis(P0.05). There was a positive correlation between expression of HIF-1α and Cox-2 (r = 0.305, P0.05). Conclusion: HIF-1α and Cox-2 play the very important role in the development of gastric cancer, could be markers in diagnosis of gastric cancer and estimation of prognosis.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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