Title: Expression of Survivin protein in gastric cancer and its correlation with prognosis
Abstract: 【Objective】 To investigate the expression of the apoptosis inhibitor Survivin in gastric cancer and its correlation with prognosis so as to provide a theoretical basis for gastric cancer diagnosis, clinical treatment and prognosis.【Methods】 The expression of Survivin was detected by immunohistochemistry Streptavidin-peroxidase method in adjacent-carcinoma tissues of 60 cases, normal mucosa of 20 cases and gastric cancer of 60 cases. Together with clinical and pathological features and follow-up data, the Cox model analysis was established.【Results】 The positive expression of Survivin was 55.0%(33 / 60) in the tissues from gastric cancer, 43.3%(26 / 60) in the corresponding adjacent gastric cancer tissues, and 0.0%(0 / 20) in the normal tissues with statistical differences(P 0.05). The expression of Survivin in the gastric cancer was significantly related with clinical stage, histological grade, depth of invasion, auxiliary lymph node metastasis and organ metastasis(P 0.05); while the expression of Survivn did not show correlation to sex, age, diameter of tumors, and Her-2 status(P 0.05). The 1, 3, 5-year survival rates of the patients with low expression of Survivin were significantly higher than those of the patients with high expression with significant differences(P 0.05). Multivariate Cox regression analysis showed that organ metastasis status, lymph node metastasis, Survivin expression,diameter of tumor and clinical stage were the independent risk factors affecting the survival rate of the patients. 【Conclusion】 The abnormal expression of Survivin is closely related to the development and prognosis of gastric cancer, which suggests that Survivin expression could be used as an indicator for determination of the progress and prognosis of gastric cancer.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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