Title: The significance of COX-2,MMP-9 expression in gastric carcinoma
Abstract: Objective To investigate the expression and clinical significance of COX-2 and MMP-9 in gastric carcinoma and the relationship between COX-2 and MMP-9. Methods Immunohistochemistry test were performed to detect the expression of cases of gastric cancer for COX-2 and MMP-9 protein,and then analysis the results. Results The positive rates of COX-2,MMP-9 expression in 52 cases of gastric cancer were 78% and 70% respectively,whereas in normal tissue were rare( P 0. 05). The expression of cases of gastric cancer for COX-2 and MMP-9 protein were significant differences in different depth of the tumor invasion,TNM phage and lymph node metastasis,but no difference in gende,differentiation( P 0. 05). There were significant positive correlation between COX-2 and MMP-9( P 0. 05,r = 0. 3587). Conclusion These data suggest that the expression of COX-2 can regulate the expression of MMP-9 and both of them play an important role in metastasis of gastric carcinoma.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot