Title: Effects of glucagon-like peptide-1 on injury of neonatal mice cardiomyocytes induced by hypoxia-reoxygenation
Abstract:AIM:To study the effects of glucagon-like peptide-1(GLP-1) on the injury of neonatal mice cardiomyocytes induced by hypoxia-reoxygenation(H/R) and to explore the possible mechanism.METHODS:Cultured ne...AIM:To study the effects of glucagon-like peptide-1(GLP-1) on the injury of neonatal mice cardiomyocytes induced by hypoxia-reoxygenation(H/R) and to explore the possible mechanism.METHODS:Cultured neonatal mice cardiomyocytes were randomly divided into three groups:normal control group,H/R group,and H/R and GLP-1 group.LDH activity,apoptosis rate of cardiomyocytes and caspase-3 activity were detected.RESULTS:Compared with the normal control group,LDH activity,cardiomyocyte apoptosis rate and caspase-3 activity all increased significantly in the H/R group.Compared with the H/R group,the above three indexes all decreased in the H/R and GLP-1 groups.CONCLUSION:GLP-1 directly acts on cardiomyocytes and protects them from H/R injury mainly by inhibiting apoptosis.GLP-1 may exert its apoptotic effects through regulation of apoptotic or antiapoptotic pathways of caspase-3.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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