Title: The Influence of Tongfu Decoction on bFGF In Lung of Acute Lungn Injury Rats
Abstract: [Objective] To observe the effect on bFGF in ALI rat lung,and to approach the mechanism of Tongfu Decoction anti - ALI,so to provide experimental base on the lung and the large intestine being interior -exteriorly related theory.[Method] 180 Wistar rats were divided into 6 groups randomly;the normal control group,the model group,hexadecadrol group,Chinese herbal medicine low - dose group,medium - dose group,and high -dose group,30 rats each group.Copying ALI model by caudal vein injecting LPS,giving respectively the Chinese herbal medicine intragastric administration and Dexamethasone intraperitoneal injection half an hour later,and executing rats in 1,2,6 hour after treatment respectively,10 rats each time in each group.We observed lung histomorphology changes,detected bFGF content in lung by ELISA method synchronously. [Result]In ALI lung:bFGF contents in the model group were higher than the normal control group ( P 0.05);contents in hexadecadrol group and Chinese herbal medicine groups were lower than the model group(P 0.05);contents in Chinese herbal medicine low - dose group were higher than hexadecadrol group (P0.05);Chinese herbal medicine medium -dose group、high -dose group and hexadecadrol group had no statistical significance ( P 0.05 );contents in Chinese herbal medicine medium - dose group and high - dose group showed lower than low - dose group(P 0.05 );Chinese herbal medicine medium - dose group and high - dose group had no statistical significance (P0.05).[Conclusions] Tongfu Decoction could decrease bFGF in lung of ALI rats,medium - dose and high - dose group were better.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot