Title: Effect of Ziyinhuoxue Decoction on Oxidative Stress of Spontaneously Hypertension Rats
Abstract: Objective: To observe the effect of Ziyinhuoxue Decoction on Oxidative stress of Spontaneously Hypertension Rats.Methods: Fifty SHR rats were randomly averagely divided into five groups:blank group,Control group,low dose TCM treatment group,medium dose TCM treatment group,high dose TCM treatment group.The Control group were administered intragastrically with benazepril,and the TCM group were administered intragastrically with Ziyin Huoxue Decoction of different density.After 4 weeks,all rats were executed the protein of p22phox in hearts and kidneys.Results:Compared with the blank group,the proteins of p22phox were lower in the other groups.There was no difference in medium dose grop,compared with high dose grop.Conclusion: Ziyinhuoxue Decoction can lower the p22phox protein in hearts and kidneys of SHR,which is not as good as benazepril.There is a dose curve between the inhibition effect on expression of p22phox protein and the dose of Ziyinhuoxue Decoction,and the dose-effect relationship does not appear linear positively.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot