Title: Effect of Jianpi yiqi recipe on serum GAS and EGF concentration of rats with gastrointestinal dysfunction caused by chemotherapy
Abstract: Objective To investigate the effect of Jianpi yiqi recipe(JPYQ) on the gastrointestinal functional disorder in rat receiving chemotherapy. Methods Forty-eight rats were equally randomized into 6 groups,and they were blank control group,chemotherapy model group,mosapride citrate group(positive control group),chemotherapy+JPYQ high-dose group(high-dose group),chemotherapy+JPYQ middle-dose group(middle-dose group),chemotherapy+JPYQ low-dose group(low-dose group),each group of 8 animals.Preparation of rat chemotherapy model was used cyclophosphamide,rats in the blank control group were given intraperitoneal injection of normal saline while the rats in the other groups were given intraperitoneal injection of cyclophosphamide on experimental day 1,3 and 5.During the modeling,the rats in the medication groups were given the corresponding medicine according to the experimental design.The levels of serum gastrin(GAS) and epidermal growth factor(EGF)in rats were determined. Results Compared with blank control group,the level of EGF in model group was significantly decreased,while the level of GAS was significantly increased(P0.05).Compared with model group,the levels of EGF in high-dose JPYQ group and mosapride group were significantly increased(P0.05),while the levels of EGF in middle-dose JPYQ group and low-dose JPYQ group were no significant difference(P0.05).The level of GAS was insignificant between the medicated groups and model group and blank control group(P0.05). Conclusion There is evident therapeutic effect of Jianpi yiqi recipe on gastrointestinal dysfunction caused by chemotherapy.And it′s mechamism is
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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