Title: Detection of HLA-B27 and genetic subtypes in young soldiers with low back pain
Abstract: Objective To investigate the relationship and diagnostic significance between ankylosing spondylitis and HLAB27 antigen in soldiers in one military district by detecting the positive rate and expression intensity of HLA-B27 antigen in 2126 young soldiers with low back pain,and evaluate its clinical significance. To investigate the distribution of genetic subtypes of AS by detecting genetic subtypes of HLA-B27 in confirmed soldiers. Methods The expression of HLA-B27 antigen of peripheral blood T lymphocytes in 2126 hospital admission patients was analyzed by flow cytometry. Genetic subtypes of HLA-B27 was determined by fluorescence quantitative polymerase chain reaction assay. Results 158 patients were positive in 2126 patients. The positive rate of antigen HLAB27 was 7. 4%,and the male and female patients ' positive rates of HLA-B27 antigen were 7. 1% and 10. 0%,respectively( P 0. 01). Among the 33 confirmed AS patients with HLA-B27 antigen positivity,B*2704 and B*2705 were the main type with accounting for 51. 5% and 42. 4% respectively. Conclusion HLA-B27 is helpful for auxiliary diagnosis of AS,but is not suitable as a screening indictor of AS.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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