Title: Experimental study on the relationship between inflammation factors of pulmonary embolism and pulmonary injury
Abstract: Objective To investigate the influence ot IL-4 on experimental acute pulmonary thromboembolism (APTE).Methods 30 health New Zealand rabbits were selected and randomly divided into three groups with each group of 10 rabbits,control group was injected saline 2 ml,model group established the APTE model,and treatment group with IL-4(1μg/kg) on the disease model,observe the changes of inflammation factors(TNF-α,IL-1β).Results Compared with control group,the TNF-α,IL-1βand pH were higher,PO_2,PCO_2 were lower in the model group(P 0.01,P 0.05).Compared with model group,the TNF-α,IL- 1βand pH were decreased,PO_2,PCO_2 were increased in the treatment group(P 0.05).Conclusion The outside source IL-4 could decrease the inflammatory factors of APTE and protect lung function.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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