Title: Effects of ventilation with high concentration of carbon dioxide on pathologic and physiological indexes in acute lung injury rabbits
Abstract: Abstract Objective To obsearve pathologic and physiological indexes in ALI rabbits when vetilated with high concentration of carbon dioxide . Methods Twenty-two healthy New Zealand white rabbits were involved in this study. After confirmation of baseline stability ,six were randomly allocated to control group(Group C), the other sixteen were injected with oleic acid (0.1ml/kg) intravenously were randomized to noncapnic group(Group N,n=8) versus hypercapnic group(Group H,n=8). Some pathologic and physiological indexed were analyzed after three hours' mechanical ventilation. Results (1) Peak airway pressure in Group H was significantly lower than that in Group N and the dynamic lung compliance was significantly higher than that in Group N (P0.05).PaO 2 in Group H was significantly higher than that in Group N (PO. 05). (2) BALF cell counts, BALF protein content and lung tissue wet/dry ratio in Group H were significantly lower than that in Group N (P0.05) . (3) Lung tissue myeloperoxidase in Group H was significantly lower than that in Group N (P0.05). (4) Histologic damage in Group N was significantly severer than that in Group H (PO. 05). (5)PaCO 2 was correlated with pH, PaO 2, dynamic lung compliance,peak airway pressure (r=-0.928, P0.001; r=0.511, 0.526, -0.506, P0.05,).Conclusion Hypercapnia induced by inspiring high concentration of carbon dioxide (8%)has protective effects on ALI rabbits. The mechanisms of protection might be associated with preservation of lung mechanics, reduction in alveolar protein and attenuation of PMN sequestration.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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