Title: Effect of Naoxintong Capsule on Aspirin's Antiplatelet Treatment
Abstract: Objective To investigate the effect of aspirin on platelet biochemical index in patients with cardio-cerebrovascular diseases and the influence of Naoxintong(Brain-heart unobstruction)Capsule.Methods The blood samples of 215 patients taking aspirin 100 mg per day for 7 days were collected for determination of platelet aggregation(PAG),P-selection level and TXB2 level by using arachidonic acid(AA)and adenosine diphosphate(ADP).Then they were divided randomly into aspirin group 1(n=72),still taking aspirin 100mg per day,aspirin group 2(n=70),taking aspirin 300mg per day,and Naoxintong group(n=73),taking aspirin 100mg per day and Naoxintong Capsule.One month later,their PAG,P-selection and TXB2 levels were re-examined.Results The plasma P-selection and TXB2 were in a positive correlation with AA-and ADP-induced PAG(P0.01).The plasma P-selection was in a positive correlation with TXB2(P0.01).After treatment,the AA-and ADP-induced PAG,P-selection and TXB2 among three groups were significantly lowered(P0.01).In the Naoxintong group,the AA-and ADP-induced PAG,P-selection and TXB2 were lower than those of aspirin groups(P0.05),and the ADP-induced PAG was obviously lower than that of aspirin group 1(P0.05).There was no significant difference in the side-effect incidence among three groups.Conclusion The combination of Naoxintong with aspirin can reinforce the effect of antiplatelet without increased side-effect.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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