Title: Influence of Tongxinluo capsule on plasma levels of lysophosphatidic acid in patients with transient ischemic attack
Abstract: Objective To investigate the action of lysophosphatidic acid(LPA) in the process of transient ischemic attack(TIA) and to observe whether treatment with Tongxinluo capsule decreases LPA levels of patients with TIA and the episode of TIA.Methods Ninety-two patients with TIA were randomly divided into three treatment groups:treatment group with Tongxinluo capsule(n=31),treatment group with aspirin(n=31) and combined treatment groups(n=30).31 healthy adults were selected as normal controls.Patients in treatment group with Tongxinluo capsules were treated with Tongxinluo capsule 4 pills for 3 times a day.Patients in treatment group with aspirin were treated with aspirin 100 mg for once a day.Patients in combined treatment group were treated with Tongxinluo capsule 4 pills for 3 times a day,and with aspirin 100 mg for once a day.All of them were treated for 30 days consecutively.Blood samples were taken for measuring the level of LPA before and after the treatment respectively.The effects of Tongxinluo capsule and aspirin on plasma LPA level were observed,compared with control group,and the incidences of TIA and hemorrhagic complication were recorded within 6 months.Results The level of LPA before treatment in treatment group with Tongxinluo capsule,treatment group with aspirin and combined treatment group was respectively(4.91±0.92) μmol/L,(4.55±0.98) μmol/L,(4.67±0.94) μmol/L,which was significantly higher than that in control group(1.64±1.02) μmol/L(all P0.01).After the treatment for 30 days,the average level of LPA in treatment group with Tongxinluo capsule,treatment group with aspirin and combined treatment group was respectively(2.56±1.03) μmol/L,(2.49±0.99) μmol/L,(1.52±0.85) μmol/L,and decreased significantly(P0.01),and that in combined treatment group was the lowest.The incidence of TIA within 6 months in combined treatment group(23.3%) was the lowest compared with Tongxinluo capsule treatment group(41.9%) and aspirin treatment group(54.8%)(all P0.05).Hemorrhagic complication in three treatment group was infrequent.Conclusion Plasma LPA level increases significantly in patients with TIA.The treatment with Tongxinluo capsule or aspirin may reduce plasma LPA level and the frequency of ischemic events.Combined treatment with Tongxinluo capsule and aspirin may bring better effect.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot