Title: Effect of sodium ozagrel on neurological function and serum adiponectin levels in patients with acute cerebral infarction
Abstract: Objective To explore the effect of sodium ozagrel on neurological function and serum adiponectin levels in patients with acute cerebral infarcion.Methods 240 patients with acute cerebral infarction were randomly divided into ozagrel group(n=120) and aspirin group(n=120).Both groups were given blood pressure regulation,lipid lowering,glycemic control,microcirculation improvement,brain cell activator and the appropriate use of dehydrating agents;ozagrel group and aspirin group were given ozagrel and aspirin on the basis of the treatments above.All the patients were treated for 14 d.The nerve function of the 2 groups was assessed by NIHSS scale,the serum adiponectin levels were measured at the same time,and the results were compared with healthy control group.Results The serum adiponectin levels of patients in ozagrel group and aspirin group were significantly lower than those of control group,and there was no significant difference in serum adiponectin and NIHSS score between ozagrel group and aspirin group,at the time of admission.At 14 d after admission,the serum adiponectin levels of ozagrel group and aspirin group increased(P0.05),but still lower than those of control group,and there were significant differences between ozagrel group and aspirin group(P0.05);the NIHSS scores of ozagrel group and aspirin group decreased(P0.05),and there were significant differences between ozagrel group and aspirin group(P0.05).Conclusion Sodium ozagrel is superior to aspirin in increasing serum adiponectin levels,improving endothelial function and promoting the recovery of neurological function of patients with acute cerebral infarction.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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