Title: [Relationship between clinicopathologic characteristics and expression of VEGF-C and VEGF-D in esophageal squamous cancer].
Abstract: To investigate the relationship between clinicopathologic characteristics and expressions of vascular endothelial growth factor-C, D (VEGF-C and VEGF-D) in esophageal squamous cancer.The tumor tissues were collected from 62 cases of esophageal squamous carcinoma, and 20 paracancerous tissues were used as control. The expressions of VEGF-C and VEGF-D were detected by immunohistochemical method, and the count of micro lymphatic density(MLD) was measured. We analyzed their relationships with tumor clinicopathologic characteristics.The expression rate of VEGF-C and VEGF-D in 62 cases of esophageal squamous carcinoma were 74% and 82%. MLD in tumor border tissue was obviously higher than that in the normal paracancerous tissue (5.387 +/- 4.986 vs. 1.900 +/- 2.245) (P < 0.05). The positive lymph node metastasis and advanced clinical stage were more common in the cases with higher expression of VEGF-C and VEGF-D. There were significant associations of high MLD with high expression of VEGF-C and VEGF-D, positive lymphod node status and advanced clinical stages. Expression levels of VEGF-C and VEGF-D correlated significantly with each other (r = 0.691, P < 0.001).VEGF-C and VEGF-D might promote lymphatic metastasis by inducing lymphangiogenesis especially at the edge of esophageal squamous carcinoma tissue.
Publication Year: 2009
Publication Date: 2009-03-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 4
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