Title: Evolution of the rifampin resistance in Mycobacterium tuberculosis
Abstract:The paper was aimed at the regularity of rpoB gene mutations at the rifampin resistant Mycobacterium tubercu-losis and the relationship between rpoB gene mutations and rifampin minimal inhibitory conc...The paper was aimed at the regularity of rpoB gene mutations at the rifampin resistant Mycobacterium tubercu-losis and the relationship between rpoB gene mutations and rifampin minimal inhibitory concentrations(MIC).The mutations in rpoB gene were the main reasons of the rifampin resistance in Mycobacterium tuberculosis.The mutations were occurred at the81bp region from codon507to codon533.About80%rifampin-resistant Mycobacterium tuberculosis strains had rpoB gene mutations in codon531or in codon526.The strains with different genotypes of rpoB gene had different drug tolerance.In common,the MIC were above64μg/mL when the strains had rpoB gene mutations in codon531.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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