Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2354073447', 'doi': None, 'title': '[Study on the characteristics of mutation on Mycobacterium tuberculosis rifampicin-resistance gene].', 'display_name': '[Study on the characteristics of mutation on Mycobacterium tuberculosis rifampicin-resistance gene].', 'publication_year': 2006, 'publication_date': '2006-11-01', 'ids': {'openalex': 'https://openalex.org/W2354073447', 'mag': '2354073447', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17402201'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17402201', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100678612', 'display_name': 'Jinghua Liu', 'orcid': 'https://orcid.org/0000-0003-3195-3798'}, 'institutions': [{'id': 'https://openalex.org/I4210146685', 'display_name': 'National Institute for Communicable Disease Control and Prevention', 'ror': 'https://ror.org/04f7g6845', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I184490438', 'https://openalex.org/I4210127390', 'https://openalex.org/I4210146685', 'https://openalex.org/I4210151987']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing-hua Liu', 'raw_affiliation_strings': ['State Key Laboratory for Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory for Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.', 'institution_ids': ['https://openalex.org/I4210146685']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070743653', 'display_name': 'Li-shui Zhang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Li-shui Zhang', 'raw_affiliation_strings': ['福建省福州市肺科医院'], 'affiliations': [{'raw_affiliation_string': '福建省福州市肺科医院', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101564588', 'display_name': 'Zhiguang Liu', 'orcid': 'https://orcid.org/0000-0003-3551-3829'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Zhi-guang Liu', 'raw_affiliation_strings': ['102206,北京,中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室'], 'affiliations': [{'raw_affiliation_string': '102206,北京,中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112636141', 'display_name': 'Mingxiang Huang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ming-xiang Huang', 'raw_affiliation_strings': ['福建省福州市肺科医院'], 'affiliations': [{'raw_affiliation_string': '福建省福州市肺科医院', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055737783', 'display_name': 'Xiuqin Zhao', 'orcid': 'https://orcid.org/0000-0003-0084-8119'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Xiu-qin Zhao', 'raw_affiliation_strings': ['102206,北京,中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室'], 'affiliations': [{'raw_affiliation_string': '102206,北京,中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100403078', 'display_name': 'Lin Wang', 'orcid': 'https://orcid.org/0000-0001-5171-2663'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Lin Wang', 'raw_affiliation_strings': ['福建省福州市肺科医院'], 'affiliations': [{'raw_affiliation_string': '福建省福州市肺科医院', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039901537', 'display_name': 'Kanglin Wan', 'orcid': 'https://orcid.org/0000-0002-3997-0237'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kang-lin Wan', 'raw_affiliation_strings': ['102206,北京,中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室'], 'affiliations': [{'raw_affiliation_string': '102206,北京,中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.151, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.387798, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 61, 'max': 68}, 'biblio': {'volume': '27', 'issue': '11', 'first_page': '973', 'last_page': '6'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10038', 'display_name': 'Tuberculosis Research and Epidemiology', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10038', 'display_name': 'Tuberculosis Research and Epidemiology', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11316', 'display_name': 'Mycobacterium research and diagnosis', 'score': 0.9635, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rpob', 'display_name': 'rpoB', 'score': 0.99112093}, {'id': 'https://openalex.org/keywords/single-strand-conformation-polymorphism', 'display_name': 'Single-strand conformation polymorphism', 'score': 0.6993661}], 'concepts': [{'id': 'https://openalex.org/C2778340795', 'wikidata': 'https://www.wikidata.org/wiki/Q24782946', 'display_name': 'rpoB', 'level': 4, 'score': 0.99112093}, {'id': 'https://openalex.org/C2777975735', 'wikidata': 'https://www.wikidata.org/wiki/Q130971', 'display_name': 'Mycobacterium tuberculosis', 'level': 3, 'score': 0.7247673}, {'id': 'https://openalex.org/C129219603', 'wikidata': 'https://www.wikidata.org/wiki/Q1788683', 'display_name': 'Single-strand conformation polymorphism', 'level': 4, 'score': 0.6993661}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6295976}, {'id': 'https://openalex.org/C2778607973', 'wikidata': 'https://www.wikidata.org/wiki/Q422652', 'display_name': 'Rifampicin', 'level': 3, 'score': 0.60496384}, {'id': 'https://openalex.org/C176944494', 'wikidata': 'https://www.wikidata.org/wiki/Q1415380', 'display_name': 'Point mutation', 'level': 4, 'score': 0.529797}, {'id': 'https://openalex.org/C2994225774', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Gene mutation', 'level': 4, 'score': 0.48712468}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.4853074}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.48011303}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.46690875}, {'id': 'https://openalex.org/C49105822', 'wikidata': 'https://www.wikidata.org/wiki/Q176996', 'display_name': 'Polymerase chain reaction', 'level': 3, 'score': 0.44245607}, {'id': 'https://openalex.org/C51679486', 'wikidata': 'https://www.wikidata.org/wiki/Q380546', 'display_name': 'DNA sequencing', 'level': 3, 'score': 0.42891443}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.42463216}, {'id': 'https://openalex.org/C2781069245', 'wikidata': 'https://www.wikidata.org/wiki/Q12204', 'display_name': 'Tuberculosis', 'level': 2, 'score': 0.40890267}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.3601433}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.3459727}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.32138616}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.1933566}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.120076925}, {'id': 'https://openalex.org/C42062724', 'wikidata': 'https://www.wikidata.org/wiki/Q1209205', 'display_name': '16S ribosomal RNA', 'level': 3, 'score': 0.049875617}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000904', 'descriptor_name': 'Antibiotics, Antitubercular', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012293', 'descriptor_name': 'Rifampin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000904', 'descriptor_name': 'Antibiotics, Antitubercular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004252', 'descriptor_name': 'DNA Mutational Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012321', 'descriptor_name': 'DNA-Directed RNA Polymerases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024881', 'descriptor_name': 'Drug Resistance, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018807', 'descriptor_name': 'Polymorphism, Single-Stranded Conformational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012293', 'descriptor_name': 'Rifampin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17402201', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.85, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3179950315', 'https://openalex.org/W2510641960', 'https://openalex.org/W2417076540', 'https://openalex.org/W2407457360', 'https://openalex.org/W2392960324', 'https://openalex.org/W2392589856', 'https://openalex.org/W2372256181', 'https://openalex.org/W2354073447', 'https://openalex.org/W2179779374', 'https://openalex.org/W2153640730'], 'abstract_inverted_index': {'To': [0], 'elucidate': [1], 'the': [2, 137, 146, 153, 166], 'characters': [3], 'of': [4, 11, 17, 41, 58, 150, 156, 170], 'rpoB': [5, 18, 90, 151], 'mutation': [6, 50, 96, 113], 'in': [7, 145], 'rifampin-resistant': [8, 63, 75, 86], 'clinical': [9], 'isolates': [10], 'Mycobacterium': [12], 'tuberculosis.286': [13], 'bp': [14, 22, 38, 148], 'DNA': [15, 39], 'fragment': [16, 40], 'gene': [19, 91], 'including': [20, 61], '81': [21, 147], 'code': [23], 'region': [24], '(rifampin': [25], 'resistance': [26], 'deteremination': [27], 'region,': [28], 'RRDR)': [29], 'was': [30, 53, 92, 115], 'analyzed': [31, 97], 'by': [32, 51, 82, 98, 130], 'PCR-single-strand': [33], 'conformation': [34], 'polymorphism(SSCP).': [35], 'The': [36, 111], '286': [37], 'each': [42], 'strain': [43, 126], 'which': [44, 102], 'had': [45], 'been': [46], 'proved': [47], 'to': [48, 79, 160], 'have': [49, 80], 'PCR-SSCP': [52, 83, 131], 'then': [54], 'sequenced.': [55], '110': [56], 'strains': [57, 68, 72, 76, 87, 122], 'M.': [59, 157], 'tuberculosis,': [60], '73': [62], 'strains,': [64], '11': [65], 'rifampin-susceptible': [66, 120], 'drug-resistant': [67, 121], 'and': [69, 108, 123, 143, 163], '26': [70], 'drug-susceptible': [71, 125], 'were': [73, 77, 127, 152, 165], 'studied.47': [74], 'detected': [78, 129], 'mutations': [81, 138], 'method.': [84, 132], '76.6%': [85], 'showed': [88, 135], 'that': [89, 136], 'carrying': [93], 'single': [94], 'point': [95], 'direct': [99], 'sequencing': [100], 'technique,': [101], 'mainly': [103], 'located': [104, 139], 'at': [105, 140], '531-Ser': [106, 162], '(61.1%)': [107], '526-His': [109, 142, 164], '(25.0%).': [110], 'combined': [112], 'rate': [114], '23.4%.': [116], 'In': [117], 'addition,': [118], '2': [119], '1': [124], 'mutated,': [128], 'Sequencing': [133], 'results': [134], '511-Leu,': [141], '535-Pro.Mutations': [144], 'RRDR': [149], 'main': [154], 'reasons': [155], 'tuberculosis': [158], 'resistant': [159], 'rifampin.': [161], 'most': [167], 'common': [168], 'positions': [169], 'mutations.': [171]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2354073447', 'counts_by_year': [], 'updated_date': '2024-12-08T17:16:22.485736', 'created_date': '2016-06-24'}