Publication Information

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'TB': [22], 'challenging;': [24], 'successful': [25], 'treatment': [26, 51], 'requires': [27], 'a': [28, 37, 175], 'long': [29], 'course': [30], 'multiple': [32], 'antibiotics.': [33], 'Rifampicin': [34], '(RIF)': [35], 'first-line': [38], 'drug': [39], 'for': [40, 67], 'treating': [41], 'TB,': [42], 'development': [45], 'RIF-resistant': [47], 'M.': [48, 202], 'makes': [50], 'even': [52], 'more': [53], 'difficult.': [54], 'To': [55, 97, 149], 'determine': [56], 'mechanism': [58], 'RIF': [60, 81, 102, 141, 154, 187, 199], 'resistance': [61, 82, 155, 200], 'in': [62, 144, 201], 'these': [63, 109], 'strains,': [64], 'we': [65, 158], 'searched': [66], 'novel': [68], 'mutations': [69, 85], 'sequencing.': [71], 'Four': [72], 'isolates,': [73], 'CDC-1,': [74], 'CDC-2,': [75], 'CDC-3,': [76], 'CDC-4,': [78], 'had': [79], 'high-level': [80], 'unique': [84], 'encoding': [86, 108], 'RpoB': [87, 89, 91, 94, 123, 147, 167, 182, 196], 'G158R,': [88, 126], 'V168A,': [90, 127], 'S188P,': [92], 'Q432insQ,': [95, 157], 'respectively.': [96], 'evaluate': [98], 'their': [99], 'correlation': [100, 152], 'with': [101], 'resistance,': [103], 'plasmids': [104], 'carrying': [105, 146, 163], 'rpoB': [106, 161], 'genes': [107], 'mutant': [110], 'proteins': [111], 'were': [112, 184], 'transfected': [113], 'into': [114, 169], 'H37Rv': [116, 145, 170], 'reference': [117], 'strain.': [118], 'The': [119], 'plasmid': [120], 'complementation': [121], 'indicated': [124], 'that': [125, 195], 'S188P': [129], 'did': [130], 'not': [131], 'affect': [132], 'MIC': [134, 139], 'RIF.': [136], 'However,': [137], 'was': [142], 'increased': [143], 'Q432insQ.': [148], 'confirm': [150], 'between': [153], 'cloned': [159], 'fragment': [162], 'insertion': [165], '(encoding': [166], 'Q432insQ)': [168], 'homologous': [172], 'recombination': [173], 'using': [174], 'suicide': [176], 'vector.': [177], 'All': [178], 'replacement': [179], 'mutants': [180], 'expressing': [181], 'Q432insQ': [183, 197], 'resistant': [185], 'to': [186], '(MIC': [188], '>': [189], '1': [190], 'mg/L).': [191], 'These': [192], 'results': [193], 'indicate': [194], 'tuberculosis.': [203]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3092857160', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-26T00:13:06.237290', 'created_date': '2020-10-22'}