Title: Relationship of rpoB gene mutation and rifampin resistance in L-forms of Mycobacterium tuberculosis
Abstract: Objective To study the relationship of rpoB gene mutation and rifampin resistance in L-forms of Mycobacterium tuberculosis.Methods Sensitivity test to rifampin in 76 clinical isolated strains from L-forms of Mycobacterium tuberculosis patients was made,and the rpoB genes and sequence analysis were detected by PCR and PCR-DS methods.Results 28 clinical isolated strains from L-forms of Mycobacterium tuberculosis were resistant to rifampin,and the rpoB gene of 20 strains had mutation.Conclusion The rpoB genes mutation in L-forms of Mycobacterium tuberculosis was the main mechanism of rifampin resistance of Mycobacterium tuberculosis.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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