Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3201980636', 'doi': 'https://doi.org/10.2147/idr.s333433', 'title': 'rpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosis', 'display_name': 'rpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosis', 'publication_year': 2021, 'publication_date': '2021-10-01', 'ids': {'openalex': 'https://openalex.org/W3201980636', 'doi': 'https://doi.org/10.2147/idr.s333433', 'mag': '3201980636', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34675557', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8502021'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/idr.s333433', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=74362', 'source': {'id': 'https://openalex.org/S2765028195', 'display_name': 'Infection and Drug Resistance', 'issn_l': '1178-6973', 'issn': ['1178-6973'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.dovepress.com/getfile.php?fileID=74362', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5115592136', 'display_name': 'Machao Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210146685', 'display_name': 'National Institute for Communicable Disease Control and Prevention', 'ror': 'https://ror.org/04f7g6845', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I184490438', 'https://openalex.org/I4210127390', 'https://openalex.org/I4210146685', 'https://openalex.org/I4210151987']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ma-chao Li', 'raw_affiliation_strings': ["State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210146685']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077910504', 'display_name': 'Jie Lu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144404', 'display_name': 'Beijing Children’s Hospital', 'ror': 'https://ror.org/04skmn292', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210144404']}, {'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jie Lu', 'raw_affiliation_strings': ["Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210144404', 'https://openalex.org/I183519381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100640062', 'display_name': 'Yao Lu', 'orcid': 'https://orcid.org/0000-0001-6725-3668'}, 'institutions': [{'id': 'https://openalex.org/I4210146685', 'display_name': 'National Institute for Communicable Disease Control and Prevention', 'ror': 'https://ror.org/04f7g6845', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I184490438', 'https://openalex.org/I4210127390', 'https://openalex.org/I4210146685', 'https://openalex.org/I4210151987']}, {'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yao Lu', 'raw_affiliation_strings': ["School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, People's Republic of China", "State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210146685']}, {'raw_affiliation_string': "School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, People's Republic of China", 'institution_ids': ['https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059004864', 'display_name': 'Tongyang Xiao', 'orcid': 'https://orcid.org/0000-0001-8483-2856'}, 'institutions': [{'id': 'https://openalex.org/I4210166055', 'display_name': 'Shenzhen Third People’s Hospital', 'ror': 'https://ror.org/04xfsbk97', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166055']}, {'id': 'https://openalex.org/I3045169105', 'display_name': 'Southern University of Science and Technology', 'ror': 'https://ror.org/049tv2d57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3045169105']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tong-yang Xiao', 'raw_affiliation_strings': ["Guangdong Key Laboratory for Diagnosis & Treatment of Emerging Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Guangdong Key Laboratory for Diagnosis & Treatment of Emerging Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210166055', 'https://openalex.org/I3045169105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061704852', 'display_name': 'Haican Liu', 'orcid': 'https://orcid.org/0000-0002-9420-1211'}, 'institutions': [{'id': 'https://openalex.org/I4210146685', 'display_name': 'National Institute for Communicable Disease Control and Prevention', 'ror': 'https://ror.org/04f7g6845', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I184490438', 'https://openalex.org/I4210127390', 'https://openalex.org/I4210146685', 'https://openalex.org/I4210151987']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hai-can Liu', 'raw_affiliation_strings': ["State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210146685']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064240120', 'display_name': 'Shiqiang Lin', 'orcid': 'https://orcid.org/0000-0001-7181-4261'}, 'institutions': [{'id': 'https://openalex.org/I61057504', 'display_name': 'Fujian Agriculture and Forestry University', 'ror': 'https://ror.org/04kx2sy84', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I61057504']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shi-qiang Lin', 'raw_affiliation_strings': ["Department of Bioinformatics, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Bioinformatics, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, People's Republic of China", 'institution_ids': ['https://openalex.org/I61057504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031227075', 'display_name': 'Da Xu', 'orcid': 'https://orcid.org/0000-0002-5819-9142'}, 'institutions': [{'id': 'https://openalex.org/I4210146685', 'display_name': 'National Institute for Communicable Disease Control and Prevention', 'ror': 'https://ror.org/04f7g6845', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I184490438', 'https://openalex.org/I4210127390', 'https://openalex.org/I4210146685', 'https://openalex.org/I4210151987']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Da Xu', 'raw_affiliation_strings': ["State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210146685']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061987364', 'display_name': 'Guilian Li', 'orcid': 'https://orcid.org/0000-0002-7656-2304'}, 'institutions': [{'id': 'https://openalex.org/I4210146685', 'display_name': 'National Institute for Communicable Disease Control and Prevention', 'ror': 'https://ror.org/04f7g6845', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I184490438', 'https://openalex.org/I4210127390', 'https://openalex.org/I4210146685', 'https://openalex.org/I4210151987']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Gui-lian Li', 'raw_affiliation_strings': ["State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210146685']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055737783', 'display_name': 'Xiuqin Zhao', 'orcid': 'https://orcid.org/0000-0003-0084-8119'}, 'institutions': [{'id': 'https://openalex.org/I4210146685', 'display_name': 'National Institute for Communicable Disease Control and Prevention', 'ror': 'https://ror.org/04f7g6845', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I184490438', 'https://openalex.org/I4210127390', 'https://openalex.org/I4210146685', 'https://openalex.org/I4210151987']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiu-qin Zhao', 'raw_affiliation_strings': ["State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210146685']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101564588', 'display_name': 'Zhiguang Liu', 'orcid': 'https://orcid.org/0000-0003-3551-3829'}, 'institutions': [{'id': 'https://openalex.org/I4210146685', 'display_name': 'National Institute for Communicable Disease Control and Prevention', 'ror': 'https://ror.org/04f7g6845', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I184490438', 'https://openalex.org/I4210127390', 'https://openalex.org/I4210146685', 'https://openalex.org/I4210151987']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhi-guang Liu', 'raw_affiliation_strings': ["State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210146685']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101949536', 'display_name': 'Lili Zhao', 'orcid': 'https://orcid.org/0000-0001-5501-0028'}, 'institutions': [{'id': 'https://openalex.org/I4210146685', 'display_name': 'National Institute for Communicable Disease Control and Prevention', 'ror': 'https://ror.org/04f7g6845', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I184490438', 'https://openalex.org/I4210127390', 'https://openalex.org/I4210146685', 'https://openalex.org/I4210151987']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Li-li Zhao', 'raw_affiliation_strings': ["State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210146685']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039901537', 'display_name': 'Kanglin Wan', 'orcid': 'https://orcid.org/0000-0002-3997-0237'}, 'institutions': [{'id': 'https://openalex.org/I4210146685', 'display_name': 'National Institute for Communicable Disease Control and Prevention', 'ror': 'https://ror.org/04f7g6845', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I184490438', 'https://openalex.org/I4210127390', 'https://openalex.org/I4210146685', 'https://openalex.org/I4210151987']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Kang-lin Wan', 'raw_affiliation_strings': ["State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210146685']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'apc_paid': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'fwci': 2.934, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 44, 'citation_normalized_percentile': {'value': 0.749287, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': 'Volume 14', 'issue': None, 'first_page': '4119', 'last_page': '4128'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10038', 'display_name': 'Tuberculosis Research and Epidemiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10038', 'display_name': 'Tuberculosis Research and Epidemiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10147', 'display_name': 'Antibiotic Resistance in Bacteria', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9928, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rpob', 'display_name': 'rpoB', 'score': 0.99965227}], 'concepts': [{'id': 'https://openalex.org/C2778340795', 'wikidata': 'https://www.wikidata.org/wiki/Q24782946', 'display_name': 'rpoB', 'level': 4, 'score': 0.99965227}, {'id': 'https://openalex.org/C2777975735', 'wikidata': 'https://www.wikidata.org/wiki/Q130971', 'display_name': 'Mycobacterium tuberculosis', 'level': 3, 'score': 0.7749144}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6116033}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.5536071}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.55344987}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.51353526}, {'id': 'https://openalex.org/C2781069245', 'wikidata': 'https://www.wikidata.org/wiki/Q12204', 'display_name': 'Tuberculosis', 'level': 2, 'score': 0.48182717}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.44480664}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.42009026}, {'id': 'https://openalex.org/C2778607973', 'wikidata': 'https://www.wikidata.org/wiki/Q422652', 'display_name': 'Rifampicin', 'level': 3, 'score': 0.41822812}, {'id': 'https://openalex.org/C176944494', 'wikidata': 'https://www.wikidata.org/wiki/Q1415380', 'display_name': 'Point mutation', 'level': 4, 'score': 0.4156086}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.37131873}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.33135825}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.18487254}, {'id': 'https://openalex.org/C42062724', 'wikidata': 'https://www.wikidata.org/wiki/Q1209205', 'display_name': '16S ribosomal RNA', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/idr.s333433', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=74362', 'source': {'id': 'https://openalex.org/S2765028195', 'display_name': 'Infection and Drug Resistance', 'issn_l': '1178-6973', 'issn': ['1178-6973'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.dovepress.com/rpob-mutations-and-effects-on-rifampin-resistance-in-mycobacterium-tub-peer-reviewed-fulltext-article-IDR', 'pdf_url': 'https://www.dovepress.com/article/download/69494', 'source': {'id': 'https://openalex.org/S4306401012', 'display_name': 'Dove Medical Press (Taylor and Francis Group)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502021', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34675557', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/idr.s333433', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=74362', 'source': {'id': 'https://openalex.org/S2765028195', 'display_name': 'Infection and Drug Resistance', 'issn_l': '1178-6973', 'issn': ['1178-6973'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.86}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1856192699', 'https://openalex.org/W1932561138', 'https://openalex.org/W1974681913', 'https://openalex.org/W1985074078', 'https://openalex.org/W1998589707', 'https://openalex.org/W2035642719', 'https://openalex.org/W2056981303', 'https://openalex.org/W2057434770', 'https://openalex.org/W2068372433', 'https://openalex.org/W2080756679', 'https://openalex.org/W2081502785', 'https://openalex.org/W2083262622', 'https://openalex.org/W2104818573', 'https://openalex.org/W2112510426', 'https://openalex.org/W2116980203', 'https://openalex.org/W2119603196', 'https://openalex.org/W2135484028', 'https://openalex.org/W2137758606', 'https://openalex.org/W2152915987', 'https://openalex.org/W2160529344', 'https://openalex.org/W2238396700', 'https://openalex.org/W2256932788', 'https://openalex.org/W2523414064', 'https://openalex.org/W2567140333', 'https://openalex.org/W2604824245', 'https://openalex.org/W2736232066', 'https://openalex.org/W2754229060', 'https://openalex.org/W2765220300', 'https://openalex.org/W2778637909', 'https://openalex.org/W2790031511', 'https://openalex.org/W2800888530', 'https://openalex.org/W2803169614', 'https://openalex.org/W2887177665', 'https://openalex.org/W2914167105', 'https://openalex.org/W2918154604', 'https://openalex.org/W3037117505', 'https://openalex.org/W3089153494', 'https://openalex.org/W3134517924', 'https://openalex.org/W3155417588', 'https://openalex.org/W3163682376'], 'related_works': ['https://openalex.org/W4284969612', 'https://openalex.org/W3198686704', 'https://openalex.org/W3173584580', 'https://openalex.org/W3091319934', 'https://openalex.org/W2285486311', 'https://openalex.org/W2157689449', 'https://openalex.org/W2148656381', 'https://openalex.org/W2109629526', 'https://openalex.org/W2106672557', 'https://openalex.org/W1976307657'], 'abstract_inverted_index': {'To': [0], 'investigate': [1], 'the': [2, 5, 25, 43, 67, 74, 80, 118, 123], 'mutations': [3, 60, 101, 116], 'within': [4, 66, 117], 'whole': [6, 68], 'rpoB': [7, 27, 69, 119], 'gene': [8, 28, 70, 120], 'of': [9, 58], 'Mycobacterium': [10], 'tuberculosis': [11, 31], 'and': [12, 33, 49, 85, 87, 99, 127, 129, 145], 'analyze': [13], 'their': [14, 35], 'effects': [15], 'on': [16, 21], 'rifampin': [17], '(RIF)': [18], 'resistance': [19, 152], 'based': [20], 'crystal': [22], 'structure.We': [23], 'sequenced': [24], 'entire': [26], 'in': [29, 153], '175': [30], 'isolates': [32], 'quantified': [34], 'minimum': [36], 'inhibitory': [37], 'concentrations': [38], 'using': [39], 'microplate-based': [40], 'assays.': [41], 'Additionally,': [42], 'structural': [44, 81], 'interactions': [45], 'between': [46, 83, 125], 'wild-type/mutant': [47], 'RpoB': [48, 84, 126], 'RIF': [50, 86, 90, 106, 114, 128, 134], 'were': [51, 71, 102], 'also': [52], 'analyzed.Results': [53], 'revealed': [54], 'that': [55, 95], 'a': [56], 'total': [57], '34': [59, 75], 'distributed': [61], 'across': [62], '17': [63], 'different': [64], 'sites': [65], 'identified.': [72], 'Of': [73], 'mutations,': [76], '25': [77], 'could': [78, 121, 138], 'alter': [79], 'interaction': [82, 124], 'contribute': [88], 'to': [89, 141], 'resistance.': [91, 135], 'Statistical': [92], 'analysis': [93], 'showed': [94], 'S450L,': [96], 'H445D,': [97], 'H445Y': [98], 'H445R': [100], 'associated': [103, 111, 132], 'with': [104, 112, 133], 'high-level': [105], 'resistance,': [107], 'while': [108], 'D435V': [109], 'was': [110], 'moderate-level': [113], 'resistance.Some': [115], 'affect': [122], 'thus': [130], 'are': [131], 'These': [136], 'findings': [137], 'be': [139], 'helpful': [140], 'design': [142], 'new': [143], 'antibiotics': [144], 'develop': [146], 'novel': [147], 'diagnostic': [148], 'tools': [149], 'for': [150], 'drug': [151], 'TB.': [154]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3201980636', 'counts_by_year': [{'year': 2024, 'cited_by_count': 16}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 15}], 'updated_date': '2024-12-24T05:34:29.136447', 'created_date': '2021-10-11'}