Title: Expression of KISS-1 and MMP7 in human non-small cell carcinoma and its significances
Abstract: Objective To investigate the role of KISS-1 and MMP7 in the genesis and development of NSCLC.Methods The expression of KISS-1 and MMP7 was detected in 58 NSCLC tissues and 23 normal lung tissues as control by immunohistochemical method SABC.Results The expression positive rate of KISS-1 protein in the tissue of NSCLC was significantly lower than that of the control(P0.05),the positive rate of MMP7 protein was significantly higher than that of the control(P0.05).The expression level of KISS-1 and MMP7 protein were closely related to lymph node metastasis,clinical stages(P0.05),but not to differentiations,histological classification,smoke,age,and sex(P0.05).Conclusion Abnormal expression of KISS-1 and MMP7 may play an important role in the growth and metastasis in human NSCLC.Detection of KISS-1 and MMP7 expression may be helpful to predict the prognosis of patients with NSCLC.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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Cited By Count: 1
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