Title: Expression and significance of MMP-9,TIMP-1 in non-small cell lung cancer
Abstract: Purpose To investigate the correlations of expression and biology behavior of matrix metalloproteinase 9(MMP-9)and tissue inhibitors of metalloproteinase-1(TIMP-1) in non-small cell lung cancer(NSCLC).Methods SP immunohistochemical method was used to detect the expressions of MMP-9 and TIMP-1 in 76 cases of NSCLC and adjacent normal lung tissues,and analyzed the correlation of their expression with histological types of NSCLC,tumor size,TNM staging,differentiation degree and lymph node metastasis.Results The positive expression rates of MMP-9,TIMP-1 in lung cancer tissue were higher than that in the adjacent normal lung tissue(P0.05).MMP-9,TIMP-1 expressions in NSCLC were significantly correlated with TNM stage,differentiations,lymph node metastasis(P0.05),but there were no relationship with tumor pathology classification(P0.05).Conclusion There is certain significance on detection of the expression of MMP-9,TIMP-1 in NSCLC for judging malignant degree and prognosis of tumors.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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