Title: Clinical control study of Quetiapine and Risperidone in the treatment of behavioral and psychological symptoms of dementia
Abstract: Objective:To compare the efficacy and safety of Quetiapine and Risperidone in the treatment of behavioral and psychological symptoms of dementia(BPSD).Methods:52 patients with BPSD were randomly divided into the Quetiapine group(26 cases) and the Risperidone group(26 cases),treatment for 8 weeks.Before treatment and in the 2nd,4th,8th weeksend,the efficacy were evaluated with the Behavioral pathology in Alzheimer disease rating scale(Behave AD),the side effects were assessed with Treatment Emergent Symptom Scale(TESS).Results:After treatment the Behave AD scores in the both groups decreased significantly(P0.01).There was no significant difference between the two groups(P0.05).The TESS scores of the Quetiapine group was lower than the Risperdone group,there was significant difference(P0.05).Conclusion:Quetiapine and Risperidone have similar therapeutic effects in the treatment of BPSD,the doses is fewer the safety is higher.The adverse reactions of Quetiapine are less than Risperidone,more adapted to the treatment of elderly patients.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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