Title: A comparative study of quetiapine and risperidone in treatment of mental disorders due to vascular disease in the advanced elderly
Abstract: Objective To compare the efficacy and side effects of quetiapine and risperidone in treatment of mental disorders due to vascular disease in the advanced elderly. Methods A total of 68 elderly with mental disorders due to vascular disease were randomly assigned to receive quetiapine or risperidone for 6 weeks. The Positive and Negative Syndrome Scale (PANSS),Clinical Global Impression (CGI-SI) and Treatment Emergent Symptom Scale (TESS) were adopted to evaluate the efficacy and side effects at baseline and after 1, 2, 4 and 6 week treatment. Results ( 1 ) After 6 week treatment, the response rate between the quetiapine and the risperidone groups was similar (72% vs. 71%, X2 =0. O06,P >0. 05). (2)The PANSS scores in both groups decreased significantly ( P 0. 05). (4)The CGI-SI score was not significantly different between groups from 1 week to 6 week treatment. (Z1w= 0. 57, Z2w = 0. 74, Z4w =0. 68,Z6w = 0. 61, all P > 0. 05). (5) The TESS showed the rate and severity of side effects did not differ between the two groups ( P > 0. 05 ). The co-medications for anxiety was significantly less frequent in quetiapine than risperidone group ( X2 = 6. 224, P < 0. 05). Conclusion Quetiapine and risperidone both provide valuable treatment options for the advanced elderly with mental disorders due to vascular disease.
Key words:
Aged; Cerebrovascular disorders; Mental disorders; Risperidone; Quetiapine
Publication Year: 2009
Publication Date: 2009-08-05
Language: en
Type: article
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