Title: The Clinical Curative Effect Observation and Research of Rabeprazole in Peptic Ulcer Treatment
Abstract: Objective To discuss the effect and safety of Rabeprazole in the treatment of peptic ulcer with infection of Helicobacter pylori(HP).Methods 120 peptic ulcer patients diagnosed by examination with Helicobacter pylori infection confirmed by biochip technique were randomly divided into rabeprazole group(n=62) and omeprazole group(n=58).The rabeprazole group was orally given rabeprazole 10 mg and amoxicillin 1g bid in the first week and then rabeprazole 10 mg every time.The omeprazole group was orally given omeprazole 20 mg and amoxicillin 1g bid in the first week and then omeprazole 20 mg every time.The treatment course was 4 weeks.Results There was significantly statistics difference in the time of eliminating pain in the rabeprazole group compared with that in the omeprazole group after treatment(P0.05).There were not significantly statistics differences in the dissolving rate of symptoms,the cure ratio and the total efficiency rate between the two groups after 2 weeks treatment and 4 weeks treatment(P0.05).The side effect rate was 3% in the rabeprazole groups compared with 7% in the omeprazole group.Conclusion The curative rate and the symptomatic improvement rate of rabeprazole curing H.pylori positive peptic ulcer were higher than that of omeprazole.There was no significant difference in efficacy between rabeprazole and omeprazole.The time of epigastric pain alleviation and disappearance with rabeprazole were earlier than that of omeprazole in the patients' clinical symptom.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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