Title: Clinical study on treating gastroesophageal reflux disease with PPI
Abstract: Objective To observe the effects of Omeprazole and Rabeprazole on GERD.Methods All of 200 patients with GERD were randomly divided into two groups,101 patients in omeprazole group orally received omeprazole 20 mg,2 times a day,for 4 weeks and 99 patients in rabeprazole orally received rabeprazole 20 mg,2 times a day,for 4 weeks.Clinical efficacy was observed in patients of both groups after a treatment course of 2 weeks and 4 weeks.Results The rates of efficacy in patients of Rabeprazole group and Omeprazole group were 79.79% and 60.39%,then their marked effectiveness rates in endoscopic were 84.84% and 64.35% respectively.There was significant difference between two groups(P 0.01).Thus the overall effect was not satisfied,founding marked individual differences.This results prompt Cytochrome P4502C19(CYP2C19) is the main way of PPI metabolism in the liver,the genotype is the leading cause of drug efficacy of individual differences in the direct factors,for future studies of PPI therapy for the treatment of GERD and CYP2C19 gene polymorphism and lay the foundation.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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