Title: Establishment of VX2 Liver Tumor Model in Rabbits and Study of the Imaging Manifestations
Abstract: Objective:To establish the VX2 liver tumor model in rabbits by abdominal incision as well as to study their characteristics,and to evaluate the value of ultrasonography and spiral computer tomography in monitoring the growth of tumors.Methods:The VX2 tumor piece of rabbits and cell suspension were injected into the left,right or middle lobes of 45 New Zealand white rabbits via abdominal incision.Color doppler ultrasonography,CT pre-and post-contrast dual-phase enhancement were performed in various periods after tumor implantation in all animals.Results:Of the 45 rabbits,40 were successfully implanted,the success rate of implanted neoplasia in situ was 88.8%.There were twenty five rabbits with sin- gle nodule and fifteen with multiple nodules within liver,accounting for 62.5 %,37.5% respectively.Nine rabbits had neo- plasm in situ accompanied with ectopia implantation.The tumors showed hypo-attenuation or iso-attenuation on CT plain scan,marked enhancement in arterial phase,and decrease of attenuation in portal phase after contrast administration,with enhancement of the rim of tumor.The rates of detection by CT after implantation in the second week and the third week were 46.7% and 90% respectively.Statistical difference between the two different periods was existed(X~2=4.26, P0.05).The tumors showed low echo accompanied with halo on ultrasound and hypervascular on color Doppler ultra- sonography.The positive rates of detection by ultrasound after the second week and the third week of implantation were 40. 0 % and 80 % respectively.There was statistical difference between the two different periods(X~2=4.33,P0.05).Conclu- sion:Injection via abdominal incision was a convenient and feasible method to establish VX2 liver tumor model in rabbits,yet ectopia implantation and multiple nodules could occur frequently.Color doppler ultrasonography and CT without and with contrast were accurate and reliable modalities for tumor monitoring.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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