Title: Effects of Shenqi Fuzheng Injection on Acute Experimental Myocardial Ischemia in Dogs and Rats
Abstract: Objective:To study the effects of Shenqi Fuzheng Injection on acute experimental myocardial ischemia in dogs and rats.Methods:The experiments in dogs adopted epicardiogram mapping to measure the scope and degree of myocardial ischemia,quantitative histologic assay (nitroblue tetrazolium,N BT stain) to determine the size of myocardial infarction,simultaneously measure the coronary blood flow and the level change of serum creatine kinase(CK); Myocardial ischemia reperfusion model in rats was established and size of myocardial infarction,serum content of malondialdehyde (MDA) and superoxide dismutase (SOD) activity were determined.Results:It was showed that Shenqi Fuzheng Injection could obviously alleviate the degree of myocardial ischemia (Σ ST) and the scope of myocardial ischemia (N ST); significantly reduce infarction area;markedly increase the coronary blood flow;inhibit the increase of myocardial ischemia and myocardial infarction induced serum CK activity.It was observed in rats' ischemia reperfusion model that the medicine could significantly reduce the injuried degree of myocardium.The area of myocardial infarction and the serum content of MDA decreased.Conclusion:Shenqi Fuzheng Injection possessed the inhibitory effects on acute experimental myocardial ischemia in dogs and rats.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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