Title: The protective effects of Diemailing injection on experimetal myocardial infarction in dogs
Abstract: OBJECTIVE To study the protective effects of Diemailing injection(DMLI)on experimental myocardial infarction(AMI)in dogs.METHODS The parameter of myocardial infarct size, the serum CK and LDH activity,myocardial metabolism,free radicals and coronary circulation etc were determined by using the model of ligation of LAD in the anaesthetized open chest dogs.RESULTS In dogs treated with DMLI (in a dosage of 2,4 g·kg -1 iv infusion)the myocardial infarct size,the activity of serum CK?LDH and the contents of serum FFA and LPO were decreased,whereas the activity of serum SOD increased markedly. At the same time,myocardial blood flow was increased and coronary vascular resistance decreased significantly.CONCLUSIONS DMLI possesses a protective effect on myocardial ischemia by modifying metabolic dysfunction of FFA,inhibiting oxygen free radical mediated peroxidation of membrane lipids,enhancing endogenous antioxidase activity and increasing myocardial blood supply.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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Cited By Count: 2
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