Title: Protective effect of captopril on acute myocardial ischemia in rats
Abstract: Objective To study the protective effect of captopril on experimental myocardial ischemia in rats. Methods The model of acute myocardial ischemia in rats was induced by subcutaneous injection of isoprenaline and sublingual venous injection of pituitrin. The changes of ECG, serum activity of creatine phosphokinase (CPK),lactate dehydragenase (LDH), aspartate aminotransferase (AST),nitrogen momoxidum(NO),malondialdehyde (MDA) and total superoxide dismutase (T-SOD)were measured in experiment.Results Captopril significantly improved the extents of abnormal rising and lowering of ST segment(P0.05), decreased the activities of serum CPK, LDL, AST and MDA (P0.05,P 0.01) , increased the activity of SOD and NO in myocardial ischemia of rats. Conclusion Captopril can protect myocardium in rats with experimenta myocardial ischemia.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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