Title: Effect of nicotinamide on myocardial ischemia induced by isoproterenol in rat
Abstract: Objective To research the protective effect of ulcotinamide on isoproterenol- induced myocardial ischemia rat.Methods Tweoty-one Wistur ratS were devided into normal control group, untreated myocardial ischemia group and nicotinamde treated myocardial ischemia group.The mycardial ischemia model was established in rats by subcutaneous injection of isoproterenol.The levels of creatine Phosphokinase (CPK), and factate dehydrogenace (LDH) in serum were measured and the changes of myocardial tissue were observed in all rats. Results Compared with untreated myocardial ischemia group, the leveIs of CPK and LDH in serum of nicotinamide- treated myocardial ischemin group were reduced obvinusly (P0.05) and the myocardis1 tissue injury was less severe.Conclusinn Nicotinamide may Play a protective role in isoproterenal- induced myocardial iachemia rats.
Publication Year: 1997
Publication Date: 1997-01-01
Language: en
Type: article
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