Title: Efficacy and Safety Analysis of Raw Rhubarb for Treatment of Severe Acute Pancreatitis
Abstract: Objective: To explore the effect of raw rhubarb on the clinical curative effect,liver function and systemic inflammatory reaction of patients with severe acute pancreatitis. Methods: 68 cases of patients with severe acute pancreatitis were selected and divided into two groups randomly( n1 = n2 = 34). Patients in control group were given conventional comprehensive therapy,while those in observation group were given raw rhubarb liquid on base of conventional therapy. The clinical curative effect,gastrointestinal function recovery time and APACHEⅡ score were compared between groups. At the same time,peripheral blood of patients was extracted and detected for liver function( ALT,AST,TBIL) and inflammation degree( IL- 1,IL- 6,bacterial endotoxin). Results: The high- effective rate( 52. 9% VS 39. 4%,χ2= 3. 886,P = 0. 042) and effective rate( 85. 3% VS 61. 8%,χ2= 4. 836,P = 0. 026) of observation group were both higher than those of control group. The recovery time for hemodiastase,borborygmus,anus exhausting and cacation of observation group were all shorter than those of control group( t = 12. 205,15. 123,5. 875,3. 066; P = 0. 000,0. 000,0. 001,0. 017) and the APACHEⅡ score of observation group were significantly lower than that of control group( t = 10169,P = 0. 000). There was no significance in liver function and inflammation degree between groups before treatment,while the ALT,AST,TBIL,IL- 1,IL- 6 and bacterial endotoxin levels of observation group were significantly lower than those of control group after treatment( t = 4. 538,3. 739,2. 911,3. 408,2. 565,4. 088; P = 0. 004,0. 011,0. 038,0. 013,0. 046, 0. 007). Conclusion: Rhubarb has positive role on promoting digestive function and reducing systemic inflammatory reaction in the treatment of patients with severe acute pancreatitis.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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