Title: Therapeutic effect of new immunosuppressive therapy on secondary infection in patients with severe acute pancreatitis
Abstract: Objective To explore the clinical effect of new immunosuppressive treatment on secondary infection in patients with severe acute pancreatitis(SAP).Methods Eighty SAP patients complicated with secondary infection were randomly divided into observation group(n=43)and control group(n=37).Control group received conventional treatment,and observation group was given new immunotherapy besides the conventional treatment.Both groups were treated for 14 days.The therapeutic effect was evaluated in two groups,and white blood cell counts,endotoxin,CD4+and CD8+were detected before and after 7-and 14-day treatment.Results The curative rate and total effective rate were23.26% and 88.37%in observation group,higher than those in control group(5.41%,67.57%)(P0.05).After 7-and 14-day treatment,the white blood cell counts((11.45±0.13),(9.49±0.09)×109/L)and endotoxin((0.550±0.017),(0.320±0.043)EU/L)were significantly lower than those before treatment(15.84±0.28)×109/L,(0.780±0.064)EU/L)in observation group(P0.05).CD4+((1.64±0.80)%,(1.87±0.89)%)and CD8+((1.52±0.75)%,(1.78±0.44)%)after 7-and 14-day treatment were significantly higher than those before treatment((1.20±0.58)%,(1.42±0.38)%)in control group(P 0.05),and CD4+((2.17±0.71)%,(2.68±0.92)% and CD8+((2.28±0.66)%,(2.55±0.58)%)after 7-and 14-day treatment were significantly higher than those before treatment((1.22±0.63)%,(1.57±0.47)%)in observation group(P0.05),showing significant differences in all indexes between two groups(P 0.05).Conclusion New immunosuppressive therapy in addition to conventional therapy can improve the therapeutic effect,reduce inflammation,increase immune function and improve the prognosis for SAP patients complicated with secondary infection.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot