Title: Expression of p53 protein and VEGF in human laryngeal carcinoma
Abstract: Objective To detect the relationship between the expression of p53 protein and VEGF in human laryngeal carcinoma, and calculate the average density of intratumoral microvessel. Methods The expression of p53, VEGF and the intratumoral microvessel density were confirmed in 62 cases of laryngeal carcinoma by S-P immunohistochemical methods. The relations among the expression of p53, VEGF and the intratumoral density of microvessel were analysed by SPSS software. Results Of the 62 cases, 33 expressed p53, 38 expressed VEGF and the average density of intratumoral microvessel was ( 34.58± 11.23)mv. Twenty-five of the 33 p53 positive cases expressed VEGF, and the average density of intratumoral microvessel was ( 39.65± 10.66)mv. Sixteen cases of the 29 p53 negative cases expressed VEGF with the average density of intratumoral microvessel ( 30.45± 11.76)mv. It was found that the expression of VEGF of the p53 positive cases was higher than that of p53 negative cases. The average density of intratumoral microvessel was more than that of p53 negative cases. Conclusion The expression of VEGF and the density of intratumoral microvessel are related to the expression of p53. mut-p53 may promote the expression of VEGF in laryngeal carcinoma, thus further promoting tumor angiogenesis, invasion, and metastasis of the laryngeal carcinoma.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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