Title: The expression of vascular endothelial growth factor and microvessel density in patients with liver cancer
Abstract: Objective To discusse the expression and clinic opathologic significance of vascular endothelial growth factor(VEGF) and microvessel density(MVD) in primary liver cancer,an immunohistochemical staining.Methods The expressions of VEGF and Ⅷ factor were determined in 60 selected operation specimen from patients with primary liver carcinoma.Results It showed that the positive expression rate of VEGF in primary liver cancer was 63.3%,the MVD was (30.76±11.56).Among them,the MVD in positive VEGF expression was (46.37±15.85),and the MVD in negative expression was (18.97±8.68),there were great statistical difference between them(P0.01).The expression of VEGF had obvious correlation with the size of tumor and whether there was portal vein embolus(P0.01),and it had no correlation with the envelope,the degree of differentiation,AFP level and positive HBsAg(P0.05).Conclusion This study indicates that VEGF can facilitate the formation of microvessel of the tumor and has correlation with the growth,infiltration and metastasis of primary liver cancer.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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