Title: The relation of p53, microvessel density, and vascular endothelial growth factor expression in human colon cancer
Abstract: Objective To investigate the expression of vascular endothelial growth factor (VEGF) in colon cancer and its relation with the microvessel density (MVD) and p53 gene. Methods The expression of VEGF, p53 gene and MVD of different region of colon cancer were studied by immunohistochemical method from 68 by surgical resected specimens. Results The positive rates of VEGF, p53 and MVD in colon cancer were significantly higher than those in peritumor and normal tissue. The expression of VEGF and p53 positively correlated with depth of invasion, lymph node metastasis, distant metastasis, vessel invasion and Dukes' stage, but their relation to the histologic types was not significant. The MVD in p53(+) ( 34.6 ±12.2 ) and VEGF(+) (31.2±12.6) tumors was significantly higher than that in p53(-) and VEGF(-) tumors (15.0±7.9; 12.7±6.3, respectively, P 0.01), and MVD (36.5±11.9, P 0.01) in both p53(+) and VEGF(+) tumors was significantly higher than that in the other subgroups. A close correlation was present between MVD and VEGF expression ( P 0.01), and p53 expression correlated with both VEGF expression and MVD ( P 0.01). Conclusion It is possible that there is a p53 VEGF pathway which might regulate tumor angiogenesis in human colon cancer, p53 gene might play an important role in promoting tumor angiogenesis.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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