Title: Changes of transforming growth factor-β of human detrusor after bladder outlet obstruction induced by benign prostatic hyperplasia
Abstract: Objective: To investigate the changes of human detrusor transforming growth factor-β(TGF-β) after bladder outlet obstruction(BOO) induced by benign prostatic hyperplasia(BPH).Methods: Obstructive detrusor stability was found in 33 patients and obstructive detrusor overactivity in 21 patients; and bladder tumor in 15 men(control) who were operated on in the same period.TGF-β was measured by immunohistochemical staining.Results: The TGF-βlevels of the obstructive groups were much higher than those in the control group.There were significant differences among the three groups(P0.01).Conclusion: The TGF-β level is significantly higher after BOO,which might be correlated with denervation supersensitivity and detrusor overactivity.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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