Title: Clinical efficacy of rabeprazole combined with mosapride in the treatment of reflux esophagitis
Abstract: Objective To investigate the efficacy and safety of rabeprazole and mosapride in the treatment of reflux esophagitis.Methods 120 patients with reflux esophagitis proven by endoscope were randomly divided into two groups:The treatment group(n=60) received rabeprazole 10 mg once daily and mosapride 5 mg three times daily; The control group(n=60) received omeprazole 20 mg twice daily and mosapride 5 mg three times daily.After 6 weeks,endoscopy was performed to study the healing rate,Improvement in symptoms and adverse effects were recorded.Results After 1 week,the total symptom improvement rates in the treatment group and the control group were 75%,46.7%,There were significant differences between the two groups(P0.01); After 6 weeks,the total symptom improvement rates and the endoscopic healing rates were 95%,90%、93.3%,90%respectively,There were no statistically significant differences between the two groups(P0.05).Conclusion Rabeprazole combined with mosapride can rapidly improve the symptom of RE and is safe and effective in the treatment of reflux esophagitis.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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