Title: The expression and significance of epidermal growth factor receptor ingastric carcinoma
Abstract: - P immunohistochemical method was used to examine the expression of EGFR in
75 cases (5 normal gastric mucosas, 20 gastric mucosal dysplasias , 50 gastric carcinomas)
and 27 paracarcinous tissues. The expression of EGFR was negative in 5 normal gastric
mucosas. Statistically , the positive rates of EGFR in moderat and severe dysplasias ,
advanced gastric carcinomas , paracarcinous abnormal tissues and the group with metastasis
were significantly higher than those in slight dysplasias , early gastric carcinomas,
paracarcinous normal tissues and the group without metastasis, respectively. The results
showed that EGFR positive expression might play an important role in the process of
carcinogenesis of gastric mucosa and serve as a molecular marker of gastric premalignant
lesions. The detection of E GFR is helpful for prognosis of gastric carcinoma.
Publication Year: 1999
Publication Date: 1999-01-01
Language: en
Type: article
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