Title: Urinary Markers of Detecting Early Renal Injury in Patient with Diabetes Mellitus(DM)
Abstract: Objective To investigate detection basis of early renal injury in non-insulin dependent diabetes mellitus(NIDDM) patients.Methods Rate nephelometry was employed to measure urinary microalbumin levels,and total quantitive enzyme immunoassay for urinary retinol binding protein(RBP) levels.Urinary N-acetyl-beta-D-glucosaminidase(NAG) was determined with reaction rate assay,and urinary creatinine(Cr) with Jaffe's rate.Results The ratios of urinary mALB/Cr,RBP/Cr,NAG/Cr in the control were 1.54±0.76 mg/ml,2.75±19.1 μg/mmol,1.66±1.05 U/mmol,respectively.The ratios of RBP/Cr and NAG/Cr in patients with microalbuminuria and macroalbuminuria were significantly higher than those in controls and patients with normalbuminuria( P 0 01).Measuring three markers together would raise the positive rate to 83.1% in DM. A significant positive correlation between mALB,RBP and NAG was found.Conclusion The method is sensitive and reliable to measure mALB,RBP and NAG toge- ther for diagnose of early renal injury in NIDDM.\;
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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