Title: Early Diagnosis of Type I Diabetic Nephropathy
Abstract: Objective To clarify whether the urinary excretion of n-acetyl-β-d-glucosaminidasen(NAG),Retinol-binding protein(RBP) andβ2-microglobulin(β2-MG) can be used as indicators for the early diagnosis of type Ⅰ diabetic nephropathy.Methods A total of 47 selected patients with type Ⅰ diabetes admitted to Beijing Children's Hospital and 30 healthy controls were recruited in this study.Urine levels of albumin were measured by the radioimmunoassay;NAG,RBP,β2-MG,and IgG were determined by enzyme-linked immunosorbent assay(ELISA).Results The 47 patients were divided into two groups based on the rate of urinary excretion of albumin,group 1 patients had normal albuminuria(UAE20 μg/min);group two had microalbuminuria(UAE 20~200 μg/min);group three was normal control.The urinary level of RBP was significantly higher in patients with microalbuminuria than in the patients with normal albuminuria(P=0.046) and normal control(P=0.039).The urinary level of albumin was positively correlated with the RBP(r=0.24,P=0.032).Conclusion The urinary RBP can be a marker in diagnosis of early DN,but it is not more sensitive than UAE.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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