Title: Intestinal absorption kinetics of actarit in rats
Abstract: Objective To study the in vivo intestinal absorption kinetics of actarit in rats. Methods Single-pass perfusion method was adopted to investigate the influence of three factors,including perfusion rate,drug concentration and absorption site,on the in vivo intestinal absorption kinetics of actarit.The indicators were absorption rate constant(ka)and apparent absorption coefficient(Papp). Results Perfusion rate could significantly affect ka and Papp(P0.01).Drug concentration had little effects on ka and Papp(P0.05).ka and Papp values of intestinal sections(duodenum,jejunum and ileum)showed no significant difference(P0.05).However,ka values between small intestine and colon had highly significant difference(P0.01),and Papp values between them were significantly different(P0.05). Conclusions Actarit can be easily absorbed in general intestinal segments,but the absorption window is mainly in the small intestine,and the absorption in the colon segment is relatively poor.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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