Title: Intestinal absorption kinetics of pyridostigmine bromide in rat intestine in vitro
Abstract: AIM To study the absorption characteristics of pyridostigmine bromide(PB)in rats intestine in vitro.METHODS Everted intestinal sacs were used to investigate the absorption characteristics of PB in rats.The PB concentration was determined by HPLC,the absorption rate constant(Ka)and the apparent perme-ability coefficient(Papp)were then calculated.The impact of P-glycoprotein(P-gp)inhibitor(ciclosporin and verapamil)on the absorption of PB in different intestinal segments was investigated.RESULTS The Ka values reduced according to the order:duodenum jejunum ileum colon(P 0.01).The PB concentration variation had no obvious effect on the Ka value of PB in the same intestinal segment(P 0.05).There was no significant difference in Ka values of PB among duodenum,jejunum and ileum(P 0.05).Compared with colon,there was significant difference in Ka values of PB in duodenum,jejunum and ileum(P 0.05,P 0.01).The Papp values of PB in different intestinal segments decreased according to the increase of PB concentration(P 0.05),and there was significant difference in the Papp values of PB between different intestinal segments(P 0.05,P 0.01).P-gp inhibitors had little influence on the absorption of PB(P 0.05).CONCLUSION The absorption of PB decreases according to the sequence:duodenum jejunum ileum colon.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot