Title: Clinical Observation of Atorvastatin Calcium Combined with Donepezil Hydrochloride in the Treatment of Alzheimer Disease
Abstract:OBJECTIVE:To observe clinical efficacy of atorvastatin calcium combined with donepezil hydrochloride in the treatment of mild to moderate alzheimer disease(AD).METHODS:74 patients with mild to moderat...OBJECTIVE:To observe clinical efficacy of atorvastatin calcium combined with donepezil hydrochloride in the treatment of mild to moderate alzheimer disease(AD).METHODS:74 patients with mild to moderate AD in our hospital were randomly divided into combination group and control group.The combination group received atorvastatin calcium 20 mg combined with donepezil 5 mg orally once a day,while the control group received donepezil hydrochloride 5 mg orally once a day for 1 year.The level of blood lipid and cognitive function were determined before treatment and 3,6,and 12 months after treatment.Mini-Mental State Examination(MMSE),Clinical Dementia Rating(CDR),and Activities of Daily Living(ADL) scores were used for the evaluation of cognitive function.The adverse drug reactions were recorded before and after treatment.The changes of creatinine,blood urea nitrogen,glutamic-oxalacetic transminase and glutamic-pyruvic transminase were also observed before and after treatment.RESULTS:After treatment,the levels of TC,LDL-C and HDL-C were significantly improved in combination group(P0.01),whereas the control group did not show any such improvement(P0.05).There were significant differences in scores of MMSE,CDR and ADL between 2 groups before and after treatment.The scores of MMSE,ADL and CDR were significantly improved in combination group 6 and 12 months after treatment,compared with control group(P0.01).No significant adverse drug reaction was found in 2 groups.CONCLUSIONS:Atrovstatin calcium can relieve cognitive function of patients with mild to moderate AD with good safety.Read More
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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Cited By Count: 1
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