Title: Clinical observation of atorvastatin calcium combined with Jiangzhitongmai capsules in treatment of hyperlipidemia
Abstract:Objective To observe the efficacy and safety of atorvastatin calcium combined with Jiangzhitongmai capsules in the treatment of hyperlipidemia.Methods Eighty patients with hyperlipidemia were randomly...Objective To observe the efficacy and safety of atorvastatin calcium combined with Jiangzhitongmai capsules in the treatment of hyperlipidemia.Methods Eighty patients with hyperlipidemia were randomly divided into two groups.The treatment group,consisting of 40 patients,took Jiangzhitongmai capsules orally 3 pieces/day and 3 times/ day and took atorvastatin calcium 20 mg orally every night before sleep.The control group,consisting of 40 patients,took atorvastatin calcium 20 mg orally every night before sleep.For both groups,4 weeks was 1 treatment course and the treatment lasted for 8 weeks.The blood lipid parameters(TC,TG,LDL-C and HDL-C),liver and kidney function,creatine kinase and adverse reactions before medication and at the end of the 4th and 8th week of medication were observed.Results The two groups of patients were not significantly different in the pre-treatment blood lipid level(P 0.05).After medication,the TC,TG and LDL-C levels of both groups reduced significantly compared to those before medication and reduced more significantly after 8 weeks(P0.05 for all).The TC,TG and LDL-C levels of the treatment at the end of the 4th and 8th week of medication reduced significantly compared to those of the control group(P 0.05 for all).After treatment,the HDL-C levels of both groups increased to varying degrees and increased more significantly after 8 weeks(P0.05 for all),but there were no significant differences between the two groups(P0.05).The total effective rate of the treatment group was 90.00%(36/40),which was significantly higher than the 67.50%(27/40) of the control group,with statistically significant difference between the two groups(P0.05).During treatment,no obvious adverse reactions were observed in either group.Conclusion Atorvastatin calcium combined with Jiangzhi ongmai capsules have obvious effect on reducing TC,TG and LDL-C and increasing HDL-C,causes mild adverse reactions and is safe to use.Read More
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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