Title: Therapeutic effect of atorvastatin plus nimodipine on mild cognitive impairment in patients with cerebral small vessel disease
Abstract:Objective To investigate the therapeutic effect of atorvastatin plus nimodipine on mild cognitive impairment in patients with cerebral small vessel disease.Methods Eighty-eight patients with cerebral ...Objective To investigate the therapeutic effect of atorvastatin plus nimodipine on mild cognitive impairment in patients with cerebral small vessel disease.Methods Eighty-eight patients with cerebral small vessel were divided into two groups according to different treatment methods,with 44 patients in each group.Observation group was treated with atorvastatin plus nimodipine,and control group was treated with nimodipine,for 6months as one course.The therapeutic effect,the adverse reaction,the levels of total cholesterol(TC),triacylglycerol(TG),low density lipoprotein-cholesterol(LDL-C)and high density lipoprotein-cholesterol(HDL-C)were compared between two groups.The changes of Montreal Cognitive Assessment(MoCA)scores and activities of daily living(ADL)were observed.Results The total effective rate was 95.45%in observation group,significantly higher than that in control group(72.73%)(P0.01),and there was no significant difference in the incidence of adverse reaction between two groups(9.09%,4.55%)(P0.05).The levels of TC,TG and LDL-C decreased after treatment((4.71±0.88),(1.97±0.40),(2.37±0.47)mmol/L)in comparison with those before treatment((5.80±0.95),(2.58±0.62),(3.36±0.76)mmol/L)in observation group(P0.01),and lower than those in control group after treatment((5.49±0.83),(2.42±0.49),(3.22±0.63)mmol/L)(P0.01).The scores of MoCA and ADL were higher after treatment in observation group(21.70±3.73,67.39±10.03)than those in control group(19.73±2.83,62.16±9.55)(P0.05).Conclusion Atorvastatin plus nimodipine can achieve a satisfactory effect on mild cognitive impairment in patients with cerebral small vessel disease,with mild adverse reaction.Read More
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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