Title: Effect of atorvastatin on serum high sensitivity C-reactive and S-100β protein in patients with ACI
Abstract:Objective To observe the effect of atorvastatin on serum high sensitivity C-reactive protein(hs-CRP) and S-100β protein in patients with acute cerebral infarction(ACI).Methods Seventy-six patients wit...Objective To observe the effect of atorvastatin on serum high sensitivity C-reactive protein(hs-CRP) and S-100β protein in patients with acute cerebral infarction(ACI).Methods Seventy-six patients with ACI were randomized into two groups.One group received conventional medications(control group)and the other received additional oral 20 mg of atorvastatin per day besides the conventional treatment(treatment group).Serum concentrations of hs-CRP and S-100β protein in the two groups were measured before treatment and on 3rd,7th and 14th day respectively after treatment;the scores of modified Edinburgh-Scandinavia stroke scale(MESSS)and Barthel index(BI) were evaluated before and after treatment.Results Compared with control group,the serum levels of hs-CRP and S-100β protein in treatment group decreased significantly on 3rd,7th and 14th day after treatment(P0.01,P0.05),while scores of MESSS and BI in treatment group improved remarkably on 7th and 14th day after treatment(P0.01).The markedly effective rate and the total effective rate of treatment group were significantly higher than those of control group(P0.05).Conclusion Atorvastatin may reduce serum levels of hs-CRP and S-100β protein in ACI patients and have anti-inflammatory effect and neuroprotection role.Read More
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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