Title: Effect of irbesrtan on interleukin 6 and C reactive protein
Abstract:Objective To investigate the protective effect of kidney of irbesrtan in diabetic nephropathy rats.Methods 36 Wistar rats were randomly divided into three group,including control group,diabetic nephro...Objective To investigate the protective effect of kidney of irbesrtan in diabetic nephropathy rats.Methods 36 Wistar rats were randomly divided into three group,including control group,diabetic nephropathy group and irbesartan group.At the weekends of the 8th and the 12th,serum and urine of the rats was collected.The levels of C reactive protein,interleukin 6,glucose,creatinine,urea nitrogen in serum and 24-hour urinaryalbumin were determined.Result The levels of C reactive protein,interleukin 6,glucose,creatinine,urea nitrogen and 24-hour urinaryalbumin in diabetic nephropathy group were significantly higher than that in control group.However,the levels of C reactive protein,interleukin 6,glucose,creatinine,urea nitrogen and 24-hour urinaryalbumin in irbesartan treatment group were significantly lower than that in diabetic nephropathy group.Conclusion Irbesartan can delay the progress of the renal function impairment of diabetic nephropathy rats.It may be associated with the mechanism that irbesartan inhibits the production of C reactive protein and interleukin 6 in blood of diabetic nephropathy rats.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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Cited By Count: 1
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