Title: EFFECT OF TONIFYING QI NOURISHING YIN,CLEARING AND PROMOTING BLOOD CIRCULATION CHINESE HERBS ON TGF-β EXPRESSION IN KIDNEY OF RATS WITH MINIMAL NEPHROTIC SYNDROME
Abstract: Objective:To observe the effect of tonifying qi nourishing yin,clearing and promoting blood circulationChinese herbs on TGF-β expression in kidney of rats with minimal nephritic syndrome,to explore the mechanism of protecting kidney.Methods:48 rats were divided into normal,model,positive,Chinese herbs high,middle and low dose groups,models with minimal nephritic syndrome were made by ADR injected through caudal vein.Each group was given corresponding medicine for 4 weeks.The 24h urinary protein,serum ALB,TC,TG,BUN and SCr were determined respectively,kidney TGF-β content was detected by ELISA,and the morphologic changes of kidney were observed by electron microscope.Results:To compare with normal group,the 24h urinary protein,serum TC,TG,BUN and SCr were increased,ALB was decreased,kidney TGF-β content was raised;tonifying qi nourishing yin,clearing and promoting blood circulation Chinese herbs could reduce the 24h urinary protein,lower serum TC,TG,BUN and SCr level and elevate ALB level,lower kidney TGF-β content,repair the injured podocytic process structure of glomerular epithelial cells.Conclusion:Tonifying qi nourishing yin,clearing and promoting blood circulation Chinese herbs can inhibit the over-expression of TGF-β in minimal nephritic syndrome rats to abate the pathologic injury of kidney.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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