Title: Effect of Ulinastation on intra-abdominal hypertension and intestinal mucosa barrier in older patients with severe acute pancreatitis
Abstract: AIM : To study the effect of Ulinastation(UTI) on intra-abdominal hypertension(IAP) and intestinal mucosa barrier in older patients with severe acute pancreatitis. METHODS : To divide 48 older patients with severe acute pancreatitis into treatment group(n=24) and contral group(n=24) randomly,including continuous blood purification(CBP).Both treatment group and control group were given conventional therapy,and ulinastatin was added to the treatment group.The changes of intra-abdominal pressure,IL-6,DAO,IgA were observed and compared in 24 and 48 hours. RESULTS :The level of IAP before treatment was(17.45 ± 1.87)mm Hg,which was positively associated with the level of IL-6(P 0.01).The intra-abdominal pressure,IL-6,DAO level were decreased and IgA was increased significantly in both groups after treatment(P 0.01).Compared with the control group,there were no significant difference between these results and those of control group before treatment,but significantly the intra-abdominal pressure,IL-6,DAO level were decreased and IgA was increased significantly at 48 hours and IL-6 was decreased at 24 hours after treatment(P 0.01).CONCLUSION : The conventional therapy plus ulinastatin for older patients with acute acute pancreatitis can improve intra-abdominal hypertension and shelter the function of intestinal mucosa by anti-inflammatory effect.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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