Title: A Study of Abnormal Glucose Metabolism in Patients with Acute Coronary Syndrome
Abstract: Objective:To observe the prevalence of glucose metabolic abnormalities and explore the potential mechanism of the effect of postprandial blood glucose on prognosis in patients with acute coronary syndrome. Methods: According to OGTT,110 patients with acute coronary syndrome were enrolled and divided into three groups:diabetes mellitus group(DM)、impaired glucose tolerance group(IGT) and normal glucose tolerance group(NGT).Fasting blood glucose(FBG)、2 hours postprandial glucose(2 h PG)、malondialdehyde(MDA) and superoxide dismutase(SOD) were measured in all patients. OGTT was performed when FBG or 2hPG was abnormal. Results: Diabetes were diagnosed in 36 patients,34 patients suffered from IGT.There was significant differences in MDA(P 0.001) and in SOD(P 0.001) between abnormal glucose metabolism group and NGT group.A remarkably positive correlation existed between 2 h PG and MDA(r= 0.137). The differences in MDA and in SOD between DM group and IGT group were not significant(P 0.05). Conclusion: ACS patients are commonly associated with glucose abnormalities.Most of these patients are diagnosed with OGTT after hospitalization. Oxidative stress phenomenon found in ACS patients with DM also exists in ACS patients with IGT,suggesting that both IGT and DM may be risk factors related with cardiovascular events through similar mechanism.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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